Read the original on Steam ↗Blender 4.2.21 LTS features important bug fixes. It is released on the v4.2 - Stable - LTS branch.
You can switch to this by right-clicking on the Blender entry in your library, select Properties.... Open the Betas tab and select v4.2 - Stable - LTS.
Patch Notes
* Blender crashes consistently when setting a render region in camera view. (#157967)